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供biovendor Fibroblast Growth Factor 21 Mouse/Rat ELISA 欣博盛供
貨號：RD291108200R
名稱：Fibroblast Growth Factor 21 Mouse/Rat ELISA
規(guī)格：96 wells (1 kit)
產(chǎn)品描述：
FGFs是20多個小（約17-26kDa）分泌肽的家族。這些蛋白的最初特征集中在它們刺激成纖維細(xì)胞增殖的能力上。這種有絲分裂活性通過FGF受體（FGFRS）1、2或3介導(dǎo)。第四個密切相關(guān)的酪氨酸激酶受體（fgfr4）能夠結(jié)合fgfs，但不會導(dǎo)致有絲分裂反應(yīng)。 FGFs通過高親和力FGF受體（fgfrs）的至少5個不同亞家族調(diào)節(jié)細(xì)胞活性：fgfr-1、-2、-3和-4，所有這些亞家族都具有固有的酪氨酸激酶活性，除fgfr-4、多重剪接亞型和fgfr-5外，都缺乏細(xì)胞內(nèi)激酶域。越來越多的證據(jù)表明，F(xiàn)GFs對調(diào)節(jié)葡萄糖和脂質(zhì)的體內(nèi)平衡很重要。在β細(xì)胞中過度表達(dá)顯性負(fù)性形式的FGFR-1會導(dǎo)致小鼠糖尿病，這意味著正常的β細(xì)胞功能和血糖維持需要適當(dāng)?shù)腇GF信號。FGFR-2是胰腺發(fā)育過程中的關(guān)鍵分子。此外，F(xiàn)GFR-4與膽固醇代謝和膽汁酸合成有關(guān)。研究表明，F(xiàn)GF-19能引起對飲食誘導(dǎo)的肥胖和胰島素desensitiz的抵抗，并改善糖尿病嚙齒類動物的胰島素、葡萄糖和脂質(zhì)狀況。由于這些影響，至少部分，是通過觀察到的代謝率變化介導(dǎo)的，因此，可以將FGF-19視為能量消耗的調(diào)節(jié)器。 FGF-21在肝臟中優(yōu)先表達(dá)，但對其生物活性及其作用方式的確切認(rèn)識尚不清楚。FGF-21是脂肪細(xì)胞葡萄糖攝取的有效激活劑，在轉(zhuǎn)基因小鼠中過表達(dá)時保護(hù)動物免受飲食誘導(dǎo)的肥胖，在treatment糖尿病嚙齒動物時降低血糖和甘油三酯水平。
特點：
It is intended for research use only
The total assay time is less than 3.5 hours
The kit measures FGF-21 in serum
Assay format is 96 wells
Quality Controls are mouse and rat serum based. No human sera are used
Standard is mouse recombinant protein based
Components of the kit are provided ready to use, concentrated or lyophilized
類型：Sandwich ELISA, Biotin-labelled antibody
別名：FGF-21, UNQ3115/PRO10196
物種：Mouse, Rat
樣本濃度：mouse samples: 7 μl/well
rat samples: 50 μl/well校準(zhǔn)范圍：40–2560 pg/ml
檢測限：18.4 pg/ml
應(yīng)用：Serum
運輸：At ambient temperature. Upon receipt, store the product at the temperature recommended below.
儲存/到期：Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
交叉反應(yīng)：
bovine Weak reactivity (recom. dilution 1:3)
cat Yes (recommended dilution 1:3)
dog Non-detectable
goat Yes (recommended dilution 1:6)
hamster Yes (recommended dilution 1:12)
horse Non-detectable
human Non-detectable
pig Yes (recommended dilution 1:3)
rabbit Non-detectable
rat Yes
sheep Yes (recommended dilution 1:3)
chicken Not tested
monkey Non-detectable
mouse Yes
試劑盒組成：
Antibody Coated Microtiter Strips 96 wells
Biotin Labelled Antibody Conc. (10x) 1.3 ml
Streptavidin-HRP Conjugate 13 ml
Master Standard 2 vials
Quality Control MOUSE 2 vials
Quality Control RAT 2 vials
Dilution Buffer 20 ml
Biotin-Ab Diluent 13ml
Wash Solution Conc.(10x) 100 ml
Substrate Solution 13 ml
Stop Solution 13 ml
Product Data Sheet + Certificate of Analysis 1 pc
產(chǎn)品覆蓋以下研究領(lǐng)域, 主要提供ELISA試劑盒，重組蛋白及相關(guān)抗體
凋亡(Apoptosis)
糖尿病-胰島素、C-肽、胰島素原
(Diabetology - Insulin, C-Peptide, Proinsulin)
肌生長調(diào)控
(Muscle Growth Control)
自身免疫 (Autoimmunity)
糖尿病-其他相關(guān)產(chǎn)品
(Diabetology - Other Relevant Products)
神經(jīng)組織標(biāo)志物
(Neural Tissue Markers)
血壓調(diào)節(jié)和NO代謝
(Blood Pressure Regulation And NO Metabolism)
能量代謝和體重調(diào)節(jié)
(Energy Metabolism And Body Weight Regulation)
腫瘤學(xué) (Oncology)
骨與軟骨代謝
(Bone And Cartilage Metabolism)
生長hormone和生長因子相關(guān)
(Growth Hormone And Factor-related Products)
氧化應(yīng)激 (Oxidative Stress)
心血管疾病
(Cardiovascular Disease)
免疫應(yīng)答、infect和炎癥反應(yīng)
(Immune Response, Infection And Inflammation)
胰調(diào)控分子
(Pancreatic Regulatory Molecules)
細(xì)胞粘連蛋白 (Cell Adhesion Proteins)
免疫學(xué) (Immunology)
腎臟疾病 (Renal Disease)
細(xì)胞因子、趨化因子及相關(guān)分子
(Cytokines And Chemokines And Related Molecules)
鐵代謝(Iron Metabolism)
生殖 (Reproduction)
糖尿病-自身免疫
(Diabetology – Autoimmunity)
脂蛋白代謝
(Lipoprotein Metabolism)
細(xì)胞表面蛋白
(Cell Surface Proteins (sCD) )
分泌型磷脂酶A2
(Secreted Phospholipases A2 show all)
血清學(xué) (Serology)
類固醇hormone
(Steroid Hormones)
移植 (Transplantation)
動物相關(guān)研究 (Animal Studies)
其他研究領(lǐng)域 (Others)
