供biovendor Uromodulin Human ELISA 欣博盛供
貨號:RD191163200R
名稱:Uromodulin Human ELISA
規格:96 wells (1 kit)
產品描述:
尿調節蛋白(tamm-horsfall蛋白,umod)是一種大約85kDa的糖蛋白,產生于腎小管亨勒環的厚上肢和腎小管的早期遠曲小管。它是一種跨膜蛋白,通過糖基磷酰肌醇(GPI)錨的蛋白水解酶分解分泌到尿液中。它屬于GPI家族。健康的人每天排泄數十毫克的尿調節蛋白,在尿液中形成最豐富的蛋白質。尿調節蛋白通過與細胞因子相互作用調節細胞粘附和信號轉導,并抑制鈣晶體的聚集。通過減少草酸鈣沉淀,尿調節蛋白在腎結石形成方面起到保護作用,最近對易患腎結石的THP缺乏小鼠的研究表明。THP是一種宿主防御因子,可抵抗由大腸埃希菌、沙門葡萄球菌、奇異變形桿菌和肺炎克雷伯氏菌等泌尿病原體引起的尿路infect。尿調節蛋白與大腸桿菌1型菌毛結合,從而阻斷尿路上皮細胞的定植。tamm-horsfall蛋白與其他分子和細胞相互作用,包括IL-1、IL-2、TNF、IGG、中性粒細胞、淋巴細胞和單核細胞。尿調節蛋白與中性粒細胞的結合誘導IL-8的合成,刺激呼吸爆發和脫粒,刺激趨化和吞噬。最近,全基因組關聯研究發現尿調節蛋白是慢性腎病和hypertensi的危險因素。尿調節蛋白基因突變與三種常染色體顯性腎小管間質性腎病有關,如家族性青少年高尿酸血癥性腎病(FJhn)、髓質囊性腎病(Mckd2)和腎小球系統性腎病(GCKd)。這些疾病的特點是青少年開始高尿酸血癥,痛風和進行性腎衰竭。
特點:
European Union: for in vitro diagnostic use
Rest of the world: for research use only!
The total assay time is less than 3.5 hours
The kit measures uromodulin in serum, plasma (EDTA, citrate, heparin) and urine
Assay format is 96 wells
Standard is native protein based
Quality Controls are human serum based
Components of the kit are provided ready to use, concentrated or lyophilized
類型:Sandwich ELISA, Biotin-labelled antibody
別名:Tamm-Horsfall urinary glycoprotein, THP, UMOD
物種:Human
樣本濃度:10 μl/well
校準范圍:0.5–32 ng/ml
檢測限:0.12 ng/ml
應用:Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate, Urine
運輸:At ambient temperature. Upon receipt, store the product at the temperature recommended below
儲存/到期:tore the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
交叉反應:
bovine Non-detectable
cat Non-detectable
dog Non-detectable
goat Non-detectable
hamster Non-detectable
horse Non-detectable
human Yes
pig Non-detectable
rabbit Non-detectable
rat Non-detectable
sheep Non-detectable
chicken Not tested
monkey Yes
mouse Non-detectable
試劑盒組成:
Antibody Coated Microtiter Strips 96 wells
Biotin Labelled Antibody Conc. (10x) 1.3 ml
Streptavidin-HRP Conjugate 13 ml
Master Standard 2 vials
Quality Control HIGH 2 vials
Quality Control LOW 2 vials
Dilution Buffer 20 ml
Biotin-Ab Diluent 13ml
Wash Solution Conc.(10x) 100 ml
Substrate Solution 13 ml
Stop Solution 13 ml
Product Data Sheet + Certificate of Analysis 1 pc
Biovendor是歐洲的一家生物醫藥科技公司,其科研及診斷產品事業部成立于1995年。Biovendor公司專注于研發與生產診斷及科研用途的免疫檢測試劑盒、抗體以及重組蛋白等產品。
產品覆蓋以下研究領域, 主要提供ELISA試劑盒,重組蛋白及相關抗體
凋亡(Apoptosis) |
糖尿病-胰島素、C-肽、胰島素原 (Diabetology - Insulin, C-Peptide, Proinsulin) |
肌生長調控 (Muscle Growth Control) |
自身免疫 (Autoimmunity) |
糖尿病-其他相關產品 (Diabetology - Other Relevant Products) |
神經組織標志物 (Neural Tissue Markers) |
血壓調節和NO代謝 (Blood Pressure Regulation And NO Metabolism) |
能量代謝和體重調節 (Energy Metabolism And Body Weight Regulation) |
腫瘤學 (Oncology) |
骨與軟骨代謝 (Bone And Cartilage Metabolism) |
生長hormone和生長因子相關 (Growth Hormone And Factor-related Products) |
氧化應激 (Oxidative Stress) |
心血管疾病 (Cardiovascular Disease) |
免疫應答、infect和炎癥反應 (Immune Response, Infection And Inflammation) |
胰調控分子 (Pancreatic Regulatory Molecules) |
細胞粘連蛋白 (Cell Adhesion Proteins) |
免疫學 (Immunology) |
腎臟疾病 (Renal Disease) |
細胞因子、趨化因子及相關分子 (Cytokines And Chemokines And Related Molecules) |
鐵代謝(Iron Metabolism) |
生殖 (Reproduction) |
糖尿病-自身免疫 (Diabetology – Autoimmunity) |
脂蛋白代謝 (Lipoprotein Metabolism) |
細胞表面蛋白 (Cell Surface Proteins (sCD) ) |
分泌型磷脂酶A2 (Secreted Phospholipases A2 show all) |
血清學 (Serology) |
類固醇hormone (Steroid Hormones) |
移植 (Transplantation) |
動物相關研究 (Animal Studies) |
其他研究領域 (Others) |